CYP2D6-debrisoquine hydroxylase gene polymorphism in multiple system atrophy.

doi:10.1002/mds.870100307

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Article

CYP2D6-debrisoquine hydroxylase gene polymorphism in multiple system atrophy.

Movement disorders : official journal of the Movement Disorder Society - 1 May 1995

Planté-Bordeneuve V, Bandmann O, Wenning G, Quinn N P, Daniel S E, Harding A E

Abstract excerpt

Molecular genetic studies of the cytochrome P450 system enzyme CYP2D6, which hydroxylates debrisoquine, have indicated an excess of mutant alleles in large series of patients with Parkinson's disease (PD) when compared with controls. We have investigated CYP2D6 polymorphism in 91 patients with mu...

Topics

Alleles
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
DNA Mutational Analysis
Gene Expression
Gene Frequency
Genotype
Humans
Mixed Function Oxygenases
Olivopontocerebellar Atrophies
Parkinson Disease
Polymorphism, Genetic

Source

Open in PubMed

Identifiers

PMID: 7651442
DOI: 10.1002/mds.870100307

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7651442-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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