Article
CYP2D6-debrisoquine hydroxylase gene polymorphism in multiple system atrophy.
Movement disorders : official journal of the Movement Disorder Society - 1 May 1995
Planté-Bordeneuve V, Bandmann O, Wenning G, Quinn N P, Daniel S E, Harding A E
Abstract excerpt
Molecular genetic studies of the cytochrome P450 system enzyme CYP2D6, which hydroxylates debrisoquine, have indicated an excess of mutant alleles in large series of patients with Parkinson's disease (PD) when compared with controls. We have investigated CYP2D6 polymorphism in 91 patients with multiple system atrophy (MSA) in order to determine if this finding is specific to PD or if there is similar evidence of...
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