Lack of association between debrisoquine 4-hydroxylase (CYP2D6) gene polymorphisms and schizophrenia.

doi:10.1097/00041444-199800810-00004

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Article

Lack of association between debrisoquine 4-hydroxylase (CYP2D6) gene polymorphisms and schizophrenia.

Psychiatric genetics - 1 Jan 1998

Jönsson E G, Dahl M L, Roh H K, Jerling M, Sedvall G C

Abstract excerpt

Debrisoquine 4-hydroxylase (CYP2D6) is a cytochrome P450 enzyme involved in the metabolism of most neuroleptics, which are the drugs of choice for the treatment of psychotic symptoms. CYP2D6 in the brain was suggested to be functionally similar to the dopamine transporter, thus possibly influenci...

Topics

Alleles
Brain
Chromosome Mapping
Cytochrome P-450 CYP2D6
Humans
Mutation
Polymorphism, Genetic
Reference Values
Schizophrenia
Sweden

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