No association between schizophrenia and polymorphisms within the genes for debrisoquine 4-hydroxylase (CYP2D6) and the dopamine transporter (DAT).

doi:10.1002/ajmg.1320600115

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Article

No association between schizophrenia and polymorphisms within the genes for debrisoquine 4-hydroxylase (CYP2D6) and the dopamine transporter (DAT).

American journal of medical genetics - 27 Feb 1995

Daniels J, Williams J, Asherson P, McGuffin P, Owen M

Abstract excerpt

It has been suggested that the cytochrome P450 mono-oxygenase, debrisoquine 4-hydroxylase, is involved in the catabolism and processing of neurotransmitters subsequent to their reuptake into target cells. It is also thought to be related to the dopamine transporter that acts to take released dopamine back up into presynaptic terminals. The present study used the association approach to test the hypothesis that...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Alleles
Base Sequence
Carrier Proteins
Case-Control Studies
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
DNA Primers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Dopamine

Dopamine Plasma Membrane Transport Proteins

Female

Genotype

Humans

Male

Membrane Glycoproteins

Source

Open in PubMed

Identifiers

PMID: 7485241
DOI: 10.1002/ajmg.1320600115

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7485241-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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No association between schizophrenia and polymorphisms within the genes for debrisoquine 4-hydroxylase (CYP2D6) and the dopamine transporter (DAT).PMID 7485241Read ↗

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An association study of debrisoquine hydroxylase (CYP2D6) polymorphisms in schizophrenia.Semantic proximity Read ↗

Debrisoquine 4-hydroxylase (CYP2D6) genetic polymorphisms and susceptibility to schizophrenia in Chinese patients from Taiwan.Semantic proximity Read ↗

Neuroleptic malignant syndrome and hydroxylase gene mutations: no association with CYP2D6A or CYP2D6B.Semantic proximity Read ↗

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The human CYP2D locus associated with a common genetic defect in drug oxidation: a G1934----A base change in intron 3 of a mutant CYP2D6 allele results in an aberrant 3' splice recognition site.Semantic proximity Read ↗

Lack of association between schizophrenia and polymorphisms in dopamine metabolism and transport genes.Semantic proximity Read ↗

Identification of the primary gene defect at the cytochrome P450 CYP2D locus.Semantic proximity Read ↗

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