Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Case-control study of debrisoquine 4-hydroxylase, N-acetyltransferase 2, and apolipoprotein E gene polymorphisms in Parkinson's disease.

Movement disorders : official journal of the Movement Disorder Society - 1 Jul 2000

Maraganore D M, Farrer M J, Hardy J A, McDonnell S K, Schaid D J, Rocca W A

Abstract excerpt

We investigated the association of Parkinson's disease (PD) with two genes encoding liver-detoxifying enzymes, debrisoquine 4-hydroxylase (CYP2D6) and N-acetyltransferase 2 (NAT2), and with one gene related to Alzheimer's disease, apolipoprotein E (APOE). In a sample of 139 unrelated PD cases and 113 control subjects, the NAT2 M3 allele was associated with PD (odds ratio = 7.9; 95% confidence interval =...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Alleles

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Apolipoproteins E

Share to Arylamine N-Acetyltransferase

Share to Case-Control Studies

Share to Cytochrome P-450 CYP2D6

Share to Parkinson Disease

Share to Polymorphism, Genetic

Source

Identifiers

PMID: 10928584
DOI: 10.1002/1531-8257(200007)15:4<714::aid-mds1018>3.0.co;2-3

Genes

APOE
NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Case-control study of debrisoquine 4-hydroxylase, N-acetyltransferase 2, and apolipoprotein E gene polymorphisms in Parkinson's disease.PMID 10928584Read ↗

Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease.Semantic proximity Read ↗

CYP2D6 allelic frequencies in young-onset Parkinson's disease.Semantic proximity Read ↗

N-acetyltransferase-2 polymorphism in Parkinson's disease: the Rotterdam study.Semantic proximity Read ↗

Debrisoquine hydroxylase gene polymorphism in familial Parkinson's disease.Semantic proximity Read ↗

Cytochrome P4502D6 (debrisoquine 4-hydroxylase) and Parkinson's disease in Chinese and Caucasians.Semantic proximity Read ↗

Association of polymorphism in cytochrome P450 2D6 and N-acetyltransferase-2 with Parkinson's disease.Semantic proximity Read ↗

A study of five candidate genes in Parkinson's disease and related neurodegenerative disorders. European Study Group on Atypical Parkinsonism.Semantic proximity Read ↗

NAT2 polymorphisms and risk for Parkinson's disease: a systematic review and meta-analysis.Semantic proximity Read ↗

Mutant debrisoquine hydroxylation genes in Parkinson's disease.Semantic proximity Read ↗

CYP2D6-debrisoquine hydroxylase gene polymorphism in multiple system atrophy.Semantic proximity Read ↗

Further evidence for the association of CYP2D6*4 gene polymorphism with Parkinson’s disease: a case control studySemantic proximity Read ↗

Association of slow acetylator genotype for N-acetyltransferase 2 with familial Parkinson's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.