Debrisoquine hydroxylase gene polymorphism in familial Parkinson's disease.

doi:10.1136/jnnp.57.8.911

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Article

Debrisoquine hydroxylase gene polymorphism in familial Parkinson's disease.

Journal of neurology, neurosurgery, and psychiatry - 1 Aug 1994

Planté-Bordeneuve V, Davis M B, Maraganore D M, Marsden C D, Harding A E

Abstract excerpt

Recent molecular genetic studies of the cytochrome P-450 system enzyme CYP2D6, which hydroxylates debrisoquine, have indicated an excess of mutant alleles in patients with Parkinson's disease compared with controls. This indicates that the CYP2D6 locus confers genetic susceptibility to Parkinson's disease. CYP2D6 polymorphism has been investigated in 48 patients with familial Parkinson's disease, from 22...

Topics

Age Factors
Alleles
Case-Control Studies
Chromosome Mapping
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
Gene Frequency
Genotype
Humans
Ireland
Lod Score

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Matched-Pair Analysis

Middle Aged

Mixed Function Oxygenases

Mutation

Parkinson Disease

Polymorphism, Genetic

Prevalence

Source

Open in PubMed Open full text

Identifiers

PMID: 8057112
DOI: 10.1136/jnnp.57.8.911
PMCID: PMC1073072

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8057112-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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