Article
Mutation frequencies of the cytochrome CYP2D6 gene in Parkinson disease patients and in families.
American journal of medical genetics - 26 Jul 1996
Lucotte G, Turpin J C, Gérard N, Panserat S, Krishnamoorthy R
Abstract excerpt
The frequencies of five mutations of the debrisoquine 4-hydroxylase (CYP2D6) gene (mutations D6-A, B, C, D, and T), corresponding to poor metabolizer (PM) phenotypes, were determined by restriction fragment length polymorphism (RFLP) and polymerase chain reaction (PCR) in 47 patients with Parkins...
Topics
- Aged
- Confidence Intervals
- Cytochrome P-450 CYP2D6
- Family
- Female
- Genotype
- Humans
- Male
- Mutation
- Parkinson Disease
- Pedigree
- Phenotype
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Reference Values
- Risk Factors