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Article

Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease.

Lancet (London, England) - 6 Jun 1992

Smith C A, Gough A C, Leigh P N, Summers B A, Harding A E, Maraganore D M, Sturman S G, Schapira A H, Williams A C, Maranganore D M

Abstract excerpt

The pathogenesis of Parkinson's disease may be influenced by genetic and environmental factors. Cytochrome P450 mono-oxygenases help to protect against toxic environmental compounds and individual variations in cytochrome P450 expression might, therefore, influence susceptibility to environmentally linked diseases. The frequency of mutant CYP2D6 alleles was studied in 229 patients with Parkinson's disease and 720...

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Share to Cytochrome P-450 Enzyme System
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 1350805
DOI: 10.1016/0140-6736(92)91196-f

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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