Article
Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease.
Lancet (London, England) - 6 Jun 1992
Smith C A, Gough A C, Leigh P N, Summers B A, Harding A E, Maraganore D M, Sturman S G, Schapira A H, Williams A C, Maranganore D M
Abstract excerpt
The pathogenesis of Parkinson's disease may be influenced by genetic and environmental factors. Cytochrome P450 mono-oxygenases help to protect against toxic environmental compounds and individual variations in cytochrome P450 expression might, therefore, influence susceptibility to environmental...
Topics
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Disease Susceptibility
- Genotype
- Humans
- Mixed Function Oxygenases
- Mutation
- Parkinson Disease
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Risk Factors