Article
An association study of debrisoquine hydroxylase (CYP2D6) polymorphisms in schizophrenia.
Psychiatric genetics - 1 Jan 1994
Dawson E, Powell J F, Nöthen M M, Crocq M A, Lanczik M, Körner J, Rietschel M, van Os J, Wright P, Gill M
Abstract excerpt
The cytochrome P450 mono-oxygenases are a group of enzymes that metabolize a variety of exogenous and endogenous compounds, some of which are potentially toxic. Individual variations in the metabolism of potential toxins could influence susceptibility to disorders having genetic and environmental components, such as schizophrenia. The frequency of two common mutant alleles of the gene for the cytochrome P450...
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