Article
An association study of debrisoquine hydroxylase (CYP2D6) polymorphisms in schizophrenia.
Psychiatric genetics - 1 Jan 1994
Dawson E, Powell J F, Nöthen M M, Crocq M A, Lanczik M, Körner J, Rietschel M, van Os J, Wright P, Gill M
Abstract excerpt
The cytochrome P450 mono-oxygenases are a group of enzymes that metabolize a variety of exogenous and endogenous compounds, some of which are potentially toxic. Individual variations in the metabolism of potential toxins could influence susceptibility to disorders having genetic and environmental...
Topics
- Alleles
- Antipsychotic Agents
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Gene Frequency
- Humans
- Mixed Function Oxygenases
- Point Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length
- Schizophrenia
- Sequence Deletion
- White People