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Article

Genetic polymorphism and Parkinson's disease in Taiwan: study of debrisoquine 4-hydroxylase (CYP2D6).

Journal of the neurological sciences - 11 Jun 1998

Lo H S, Chen C H, Hogan E L, Kao K P, Wang V, Yan S H

Abstract excerpt

Debrisoquine 4-hydroxylase (CYP2D6) is one of the cytochrome P450 enzyme families that catalyze the breakdown of a variety of exogenous and endogenous compounds. Previous reports have suggested that genetic polymorphisms of debrisoquine 4-hydroxylase are associated with susceptibility to Parkinson's disease (PD) in Caucasians. To determine if CYP2D6 also confers susceptibility to PD in Chinese patients, we...

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PMID: 9667775
DOI: 10.1016/s0022-510x(98)00094-x

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