Variant cytochrome P450 CYP2D6 allelic frequencies in Parkinson's disease.

doi:10.1002/ajmg.1320480311

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Article

Variant cytochrome P450 CYP2D6 allelic frequencies in Parkinson's disease.

American journal of medical genetics - 15 Oct 1993

Kurth M C, Kurth J H

Abstract excerpt

Aberrant detoxification of environmental agents may be the basis for an inherited predisposition to Parkinson's disease. A CYP2D6 genetic marker of the debrisoquine hydroxylase "poor metabolizer" phenotype was found to be significantly increased in Parkinson's disease patients compared to control...

Topics

Aged
Aged, 80 and over
Alleles
Cytochrome P-450 Enzyme System
Gene Frequency
Genetic Markers
Genetic Variation
Heterozygote
Homozygote
Humans
Middle Aged
Parkinson Disease
Phenotype

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