Article
Variant cytochrome P450 CYP2D6 allelic frequencies in Parkinson's disease.
American journal of medical genetics - 15 Oct 1993
Kurth M C, Kurth J H
Abstract excerpt
Aberrant detoxification of environmental agents may be the basis for an inherited predisposition to Parkinson's disease. A CYP2D6 genetic marker of the debrisoquine hydroxylase "poor metabolizer" phenotype was found to be significantly increased in Parkinson's disease patients compared to controls, as has been shown in previous studies. Presence of this marker gives an odds ratio of 1.86 for Parkinson's disease...
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