Article
Apolipoprotein E polymorphism influences not only cerebral senile plaque load but also Alzheimer-type neurofibrillary tangle formation.
Neuroscience - 1 Jun 1995
Ohm T G, Kirca M, Bohl J, Scharnagl H, Gross W, März W
Abstract excerpt
Only recently, evidence was provided that apolipoprotein E allele epsilon 4 located on Chromosome 19 is associated with late onset (i.e. senile) sporadic Alzheimer's disease. Histologically, Alzheimer's disease is associated with intraneuronal neurofibrillary changes and extraneuronal A4/beta-amy...
Topics
- Age Factors
- Aged
- Aged, 80 and over
- Alleles
- Alzheimer Disease
- Amyloid beta-Peptides
- Apolipoproteins E
- Brain
- Chromosomes, Human, Pair 19
- Genotype
- Humans
- Middle Aged
- Neurofibrillary Tangles
- Polymorphism, Genetic
- Regression Analysis