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Article

Apolipoprotein E4 promotes incipient Alzheimer pathology in the elderly.

Alzheimer disease and associated disorders - 1 Mar 1998

Warzok R W, Kessler C, Apel G, Schwarz A, Egensperger R, Schreiber D, Herbst E W, Wolf E, Walther R, Walker L C

Abstract excerpt

To evaluate the influence of the apolipoprotein E (ApoE) epsilon4 allele on the age at which Alzheimer-like lesions appear in the brain, we analyzed the degree of cerebral beta-amyloidosis and neurofibrillary tangle formation in the hippocampal formation and adjacent cortical areas 28, 27, and 36...

Topics

Aged
Aged, 80 and over
Alleles
Alzheimer Disease
Apolipoprotein E4
Apolipoproteins E
Cerebral Amyloid Angiopathy
Cerebral Cortex
Female
Genetic Predisposition to Disease
Hippocampus
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Neurofibrillary Tangles

Risk Factors

Source

Identifiers

PMID: 9539408
DOI: 10.1097/00002093-199803000-00005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9539408-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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