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Article

Neuropathological epidemiology of cerebral aging: a study of two genetic polymorphisms.

Neurobiology of aging - 1 Jan 2000

Berr C, Lambert J C, Sazdovitch V, Amouyel P, Chartier-Harlin M C, Mohr M, Heldt N, Kiesmann M, Hauw J J

Abstract excerpt

We studied whether ApoE and -219 GT (ApoE promoter) polymorphism modulates neurofibrillary tangle (NFT) and senile plaque (SP) development in aging among 190 non-institutionalized individuals (mean age 79.5 years). Analysis revealed that the mean Braak stage was higher in epsilon4 allele carriers. Once individuals with Braak stage V were excluded (n = 5), relationships between NFT and the two genotypes studied...

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PMID: 11182472
DOI: 10.1016/s0197-4580(00)00227-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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