Article
Alzheimer pathology of patients carrying apolipoprotein E epsilon 4 allele.
Neurobiology of aging - 1 Jan 2000
Heinonen O, Lehtovirta M, Soininen H, Helisalmi S, Mannermaa A, Sorvari H, Kosunen O, Paljärvi L, Ryynänen M, Riekkinen P J
Abstract excerpt
A recent report suggested that brains of Alzheimer patients homozygous for APOE epsilon 4 show increased amyloid pathology compared to APOE epsilon 3 homozygotes. We studied APOE allele frequencies in 73 AD patients and 38 controls. We also investigated relation of APOE genotypes to beta/A4 immun...
Topics
- Aged
- Aged, 80 and over
- Alleles
- Alzheimer Disease
- Amyloid beta-Peptides
- Analysis of Variance
- Apolipoproteins E
- Blood Vessels
- Brain
- Chi-Square Distribution
- Female
- Gene Frequency
- Genotype
- Humans
- Male
- Neurofibrillary Tangles
- Neurons
- Skin