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Article

High frequency of apolipoprotein E epsilon4 allele in young individuals with very mild Alzheimer's disease-related neurofibrillary changes.

Experimental neurology - 1 Sept 1998

Ghebremedhin E, Schultz C, Braak E, Braak H

Abstract excerpt

The pathological process of initial neurofibrillary (NF) changes underlying Alzheimer's disease (AD) represents the early preclinical phase of the disease. In a small percentage of individuals, these initial NF changes (Braaks' stage I of six stages) may develop at a surprisingly young age. The a...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Alleles
Alzheimer Disease
Apolipoprotein E4
Apolipoproteins E
Child
Child, Preschool
Female
Genotype
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Infant

Male

Middle Aged

Neurofibrillary Tangles

Source

Identifiers

PMID: 9743577
DOI: 10.1006/exnr.1998.6860

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9743577-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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