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Article

Blocking double-stranded RNA-activated protein kinase PKR by Japanese encephalitis virus nonstructural protein 2A.

Journal of virology - 1 Oct 2012

Tu Yu-Chun, Yu Chia-Yi, Liang Jian-Jong, Lin Elong, Liao Ching-Len, Lin Yi-Ling

Abstract excerpt

Japanese encephalitis virus (JEV) is an enveloped flavivirus with a single-stranded, positive-sense RNA genome encoding three structural and seven nonstructural proteins. To date, the role of JEV nonstructural protein 2A (NS2A) in the viral life cycle is largely unknown. The interferon (IFN)-induced double-stranded RNA (dsRNA)-activated protein kinase (PKR) phosphorylates the eukaryotic translation initiation...

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Source

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Identifiers

PMID: 22787234
DOI: 10.1128/JVI.00525-12
PMCID: PMC3457255

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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