Article
Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase.
Proceedings of the National Academy of Sciences of the United States of America - 3 Jan 2006
Su Qiaozhu, Wang Shuo, Baltzis Dionissios, Qu Li-Ke, Wong Andrew Hoi-Tao, Koromilas Antonis E
Abstract excerpt
Phosphorylation of the alpha-subunit of translation eukaryotic initiation factor-2 (eIF2) leads to the inhibition of protein synthesis in response to diverse conditions of stress. Serine/threonine RNA-dependent protein kinase (PKR) is an eIF2alpha kinase family member induced by type I IFN and activated in response to dsRNA or virus infection. Herein, we demonstrate that human PKR is a dual specificity kinase...
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