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Article

Double-stranded-RNA-activated protein kinase PKR enhances transcriptional activation by tumor suppressor p53.

Molecular and cellular biology - 1 Apr 1999

Cuddihy A R, Li S, Tam N W, Wong A H, Taya Y, Abraham N, Bell J C, Koromilas A E

Abstract excerpt

The tumor suppressor p53 plays a key role in inducing G1 arrest and apoptosis following DNA damage. The double-stranded-RNA-activated protein PKR is a serine/threonine interferon (IFN)-inducible kinase which plays an important role in regulation of gene expression at both transcriptional and translational levels. Since a cross talk between IFN-inducible proteins and p53 had already been established, we...

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Identifiers

PMID: 10082513
DOI: 10.1128/MCB.19.4.2475
PMCID: PMC84040

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Double-stranded-RNA-activated protein kinase PKR enhances transcriptional activation by tumor suppressor p53.PMID 10082513Read ↗

Identification of the interferon-inducible double-stranded RNA-dependent protein kinase as a regulator of cellular response to bulky adducts.Semantic proximity Read ↗

Involvement of the double-stranded-RNA-dependent kinase PKR in interferon expression and interferon-mediated antiviral activity.Semantic proximity Read ↗

<i>PKR</i> , a <i>p53</i> target gene, plays a crucial role in the tumor-suppressor function of <i>p53</i>Semantic proximity Read ↗

Cell Type- and Promoter-specific Roles of Ser18 Phosphorylation in Regulating p53 ResponsesSemantic proximity Read ↗

The interferon-induced double-stranded RNA-activated protein kinase induces apoptosis.Semantic proximity Read ↗

Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway.Semantic proximity Read ↗

Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression.Semantic proximity Read ↗

Induction of protein kinase PKR-dependent activation of interferon regulatory factor 3 by vaccinia virus occurs through adapter IPS-1 signaling.Semantic proximity Read ↗

Transcriptional role of p53 in interferon-mediated antiviral immunitySemantic proximity Read ↗

Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase.Semantic proximity Read ↗

Identification of functional domains of the interferon-induced enzyme PKR in cells lacking endogenous PKR.Semantic proximity Read ↗

The ataxia telangiectasia-mutated target site Ser18 is required for p53-mediated tumor suppression.Semantic proximity Read ↗

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