Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways.

The EMBO journal - 17 Mar 1997

Wong A H, Tam N W, Yang Y L, Cuddihy A R, Li S, Kirchhoff S, Hauser H, Decker T, Koromilas A E

Abstract excerpt

The interferon-inducible double-stranded RNA protein kinase PKR controls protein synthesis through the phosphorylation of eukaryotic translation initiation factor (eIF)-2. In addition to its demonstrated role in translational control, several reports have suggested a transcriptional role for PKR. Here we report that PKR is involved in IFN- and dsRNA-signaling pathways by modulating the function of the signal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to DNA

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA-Binding Proteins

Share to Mutation

Share to Phosphorylation

Share to Protein Binding

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 9135145
DOI: 10.1093/emboj/16.6.1291
PMCID: PMC1169727

Genes

STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways.PMID 9135145Read ↗

Enhanced antiviral and antiproliferative properties of a STAT1 mutant unable to interact with the protein kinase PKR.Semantic proximity Read ↗

The direct binding of the catalytic subunit of protein phosphatase 1 to the PKR protein kinase is necessary but not sufficient for inactivation and disruption of enzyme dimer formation.Semantic proximity Read ↗

The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR).Semantic proximity Read ↗

Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase.Semantic proximity Read ↗

Involvement of the double-stranded-RNA-dependent kinase PKR in interferon expression and interferon-mediated antiviral activity.Semantic proximity Read ↗

Dominant Negative Function by an Alternatively Spliced Form of the Interferon-inducible Protein Kinase PKRSemantic proximity Read ↗

The interferon-induced double-stranded RNA-activated protein kinase PKR will phosphorylate serine, threonine, or tyrosine at residue 51 in eukaryotic initiation factor 2alpha.Semantic proximity Read ↗

Direct Association of STAT3 with the IFNAR-1 Chain of the Human Type I Interferon ReceptorSemantic proximity Read ↗

West Nile Virus-Induced Interferon Production Is Mediated by the Double-Stranded RNA-Dependent Protein Kinase PKRSemantic proximity Read ↗

Identification of functional domains of the interferon-induced enzyme PKR in cells lacking endogenous PKR.Semantic proximity Read ↗

PKR Transduces MDA5-Dependent Signals for Type I IFN Induction.Semantic proximity Read ↗

Protein tyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPK and Stat1 in IFN-gamma, but not IFN-alpha, signaling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.