Article
Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways.
The EMBO journal - 17 Mar 1997
Wong A H, Tam N W, Yang Y L, Cuddihy A R, Li S, Kirchhoff S, Hauser H, Decker T, Koromilas A E
Abstract excerpt
The interferon-inducible double-stranded RNA protein kinase PKR controls protein synthesis through the phosphorylation of eukaryotic translation initiation factor (eIF)-2. In addition to its demonstrated role in translational control, several reports have suggested a transcriptional role for PKR....
Topics
- 3T3 Cells
- Animals
- Base Sequence
- DNA
- DNA-Binding Proteins
- HeLa Cells
- Humans
- Interferons
- Mice
- Mutation
- Phosphorylation
- Protein Binding
- Protein Serine-Threonine Kinases
- RNA, Double-Stranded
- STAT1 Transcription Factor