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Article

A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt.

Proceedings of the National Academy of Sciences of the United States of America - 2 Jan 2001

Aoki M, Blazek E, Vogt P K

Abstract excerpt

The oncoproteins P3k (homolog of the catalytic subunit of class IA phosphoinositide 3-kinase) and Akt (protein kinase B) induce oncogenic transformation of chicken embryo fibroblasts. The transformed cells show constitutive phosphorylation of the positive regulator of translation p70S6 kinase (S6K) and of the eukaryotic initiation factor 4E-BP1 binding protein (4E-BP1), a negative regulator of translation....

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Identifiers

PMID: 11134523
DOI: 10.1073/pnas.98.1.136
PMCID: PMC14557

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Source receipt: pubmed, retrieved 7 Sept 2026.

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