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Article

Involvement of the double-stranded-RNA-dependent kinase PKR in interferon expression and interferon-mediated antiviral activity.

Proceedings of the National Academy of Sciences of the United States of America - 12 Sept 1995

Der S D, Lau A S

Abstract excerpt

The signaling mechanisms responsible for the induced expression of interferon (IFN) genes by viral infection or double-stranded RNA (dsRNA) are not well understood. Here we investigate the role of the interferon-induced dsRNA-dependent protein kinase PKR in the regulation of IFN induction. Biological activities attributed to PKR include regulating protein synthesis, mediating IFN actions, and functioning as a...

Topics

Base Sequence
DNA, Antisense
Encephalomyocarditis virus
Gene Expression Regulation
Humans
Interferon-alpha
Interferon-beta
Interferons
Molecular Sequence Data
Monocytes
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Serine-Threonine Kinases

Suppression, Genetic

Virus Replication

eIF-2 Kinase

Source

Open in PubMed Open full text

Identifiers

PMID: 7568028
DOI: 10.1073/pnas.92.19.8841
PMCID: PMC41063

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7568028-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Involvement of the double-stranded-RNA-dependent kinase PKR in interferon expression and interferon-mediated antiviral activity.PMID 7568028Read ↗

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