Article
Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase.
Science (New York, N.Y.) - 18 Sept 1992
Koromilas A E, Roy S, Barber G N, Katze M G, Sonenberg N
Abstract excerpt
The double-stranded RNA-dependent protein kinase (dsRNA-PK) is thought to be a key mediator of the antiviral and antiproliferative effects of interferons (IFNs). Studies examining the physiological function of the kinase suggest that it participates in cell growth and differentiation by regulatin...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Binding Sites
- Cell Division
- Cell Line
- Cell Transformation, Neoplastic
- Cloning, Molecular
- DNA
- Enzyme Induction
- Gene Expression
- Humans
- Immunoblotting
- Interferons
- Mice
- Molecular Sequence Data
- Mutation
- Phosphorylation