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Article

Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase.

Science (New York, N.Y.) - 18 Sept 1992

Koromilas A E, Roy S, Barber G N, Katze M G, Sonenberg N

Abstract excerpt

The double-stranded RNA-dependent protein kinase (dsRNA-PK) is thought to be a key mediator of the antiviral and antiproliferative effects of interferons (IFNs). Studies examining the physiological function of the kinase suggest that it participates in cell growth and differentiation by regulating protein synthesis. Autophosphorylation and consequent activation of dsRNA-PK in vitro and in vivo result in...

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Identifiers

PMID: 1382315
DOI: 10.1126/science.1382315

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase.PMID 1382315Read ↗

Involvement of the double-stranded-RNA-dependent kinase PKR in interferon expression and interferon-mediated antiviral activity.Semantic proximity Read ↗

Dominant Negative Function by an Alternatively Spliced Form of the Interferon-inducible Protein Kinase PKRSemantic proximity Read ↗

The direct binding of the catalytic subunit of protein phosphatase 1 to the PKR protein kinase is necessary but not sufficient for inactivation and disruption of enzyme dimer formation.Semantic proximity Read ↗

Identification of functional domains of the interferon-induced enzyme PKR in cells lacking endogenous PKR.Semantic proximity Read ↗

Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells.Semantic proximity Read ↗

The interferon-induced double-stranded RNA-activated protein kinase induces apoptosis.Semantic proximity Read ↗

Identification of the interferon-inducible double-stranded RNA-dependent protein kinase as a regulator of cellular response to bulky adducts.Semantic proximity Read ↗

Expression of human PKR protein kinase in transgenic mice.Semantic proximity Read ↗

Protein kinase PKR catalytic activity is required for the PKR-dependent activation of mitogen-activated protein kinases and amplification of interferon beta induction following virus infection.Semantic proximity Read ↗

The murine PKR tumor suppressor gene is rearranged in a lymphocytic leukemia.Semantic proximity Read ↗

Mechanism of interferon action: evidence for intermolecular autophosphorylation and autoactivation of the interferon-induced, RNA-dependent protein kinase PKR.Semantic proximity Read ↗

Blocking double-stranded RNA-activated protein kinase PKR by Japanese encephalitis virus nonstructural protein 2A.Semantic proximity Read ↗

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