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Article

Mechanism of interferon action: evidence for intermolecular autophosphorylation and autoactivation of the interferon-induced, RNA-dependent protein kinase PKR.

Journal of virology - 1 Dec 1993

Thomis D C, Samuel C E

Abstract excerpt

The interferon-induced RNA-dependent protein kinase (PKR) is postulated to have an important regulatory role in the synthesis of viral and cellular proteins. Activation of the enzyme requires the presence of a suitable activator RNA and is accompanied by an autophosphorylation of PKR. Active PKR phosphorylates the alpha subunit of protein synthesis eukaryotic initiation factor 2, resulting in an inhibition of...

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Identifiers

PMID: 7693978
DOI: 10.1128/JVI.67.12.7695-7700.1993
PMCID: PMC238244

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Source receipt: pubmed, retrieved 7 Sept 2026.

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