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Article

Mechanism of interferon action: evidence for intermolecular autophosphorylation and autoactivation of the interferon-induced, RNA-dependent protein kinase PKR.

Journal of virology - 1 Dec 1993

Thomis D C, Samuel C E

Abstract excerpt

The interferon-induced RNA-dependent protein kinase (PKR) is postulated to have an important regulatory role in the synthesis of viral and cellular proteins. Activation of the enzyme requires the presence of a suitable activator RNA and is accompanied by an autophosphorylation of PKR. Active PKR phosphorylates the alpha subunit of protein synthesis eukaryotic initiation factor 2, resulting in an inhibition of...

Topics

Adenosine Triphosphate
Enzyme Activation
Enzyme Induction
Histidine
Humans
Interferons
Mutation
Phosphorylation
Protein Serine-Threonine Kinases
RNA, Messenger
Recombinant Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Substrate Specificity

eIF-2 Kinase

Source

Open in PubMed Open full text

Identifiers

PMID: 7693978
DOI: 10.1128/JVI.67.12.7695-7700.1993
PMCID: PMC238244

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7693978-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Mechanism of interferon action: evidence for intermolecular autophosphorylation and autoactivation of the interferon-induced, RNA-dependent protein kinase PKR.PMID 7693978Read ↗

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