An aphidicolin-resistant mutant of Chinese hamster ovary cell with altered DNA polymerase and 3' exonuclease activities.

doi:10.1016/0167-4781(95)00089-y

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Article

An aphidicolin-resistant mutant of Chinese hamster ovary cell with altered DNA polymerase and 3' exonuclease activities.

Biochimica et biophysica acta - 22 Aug 1995

Fehér Z, Mishra N C

Abstract excerpt

A comparison was made of partially purified DNA polymerases alpha, delta, epsilon and from normal Chinese hamster ovary cells and mutant cells (JK3-1-2A) resistant to aphidicolin, araA, and araC. In vitro the pol alpha from the mutant cells (1) was resistant to aphidicolin and araCTP but was sens...

Topics

Animals
Aphidicolin
CHO Cells
Cricetinae
DNA Polymerase II
DNA Polymerase III
DNA-Directed DNA Polymerase
Drug Resistance
Exonucleases
Mutation
Templates, Genetic

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