Article
Isolation and partial characterisation of a mammalian cell mutant hypersensitive to topoisomerase II inhibitors and X-rays.
Mutation research - 1 Mar 1990
Davies S M, Davies S L, Hall A G, Hickson I D
Abstract excerpt
We have isolated, following one-step mutagenesis, a Chinese hamster ovary cell mutant hypersensitive to the intercalating agent, adriamycin (4-fold compared to parental CHO-K1 cells). This agent exerts at least part of its cytotoxic action via inhibition of the nuclear enzyme, topoisomerase II. T...
Topics
- Animals
- Blotting, Western
- Catalase
- Cell Line
- Cell Survival
- Cricetinae
- Cricetulus
- DNA Damage
- Doxorubicin
- Drug Hypersensitivity
- Glutathione Peroxidase
- Hybrid Cells
- Hydrogen Peroxide
- Mutation
- Radiation Tolerance
- Topoisomerase II Inhibitors