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Article

Cisplatin resistance and regulation of DNA repair in cAMP-dependent protein kinase mutants.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Aug 1996

Liu B, Cvijic M E, Jetzt A, Chin K V

Abstract excerpt

Drug resistance in cancer poses a major problem to the success of chemotherapy. Increased resistance to the DNA-damaging chemotherapeutic drug cisplatin may be associated with a variety of factors including decreased drug accumulation, increased intracellular levels of thiols, and increased DNA repair. We have found that mutants of the Chinese hamster ovary (CHO) and the mouse adrenocortical carcinoma Y1 cells...

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PMID: 8853907

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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