Article
Mutants from V79 fibroblasts exhibiting hypersensitivity to aphidicolin and 3'-azido-3'-deoxythymidine.
Somatic cell and molecular genetics - 1 Jan 1991
Liu P K, Norwood T H
Abstract excerpt
One variant, aphhs-3 was previously isolated based on a hypersensitivity to nontoxic concentrations of aphidicolin, a specific inhibitor of DNA polymerases-alpha and delta. This variant was found to be more sensitive to temperatures above 35 degrees C and to 10 microM of 3'-azido-3'-deoxythymidin...
Topics
- Animals
- Aphidicolin
- Cell Division
- Cell Line
- Cell Survival
- Cricetinae
- Cricetulus
- DNA Replication
- DNA-Directed DNA Polymerase
- Deoxyribonucleotides
- Dideoxynucleotides
- Diterpenes
- Mutation
- Temperature
- Thymidine
- Thymine Nucleotides
- Zidovudine