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Article

Characterization of eukaryotic DNA polymerases: aphidicolin resistant mutants of Neurospora with altered DNA polymerase.

Progress in clinical and biological research - 1 Jan 1990

Mishra N C, Almasan A, Cooley M

Abstract excerpt

Sucrose density gradient analysis of Neurospora cell free extract showed at least three distinct peaks of enzyme activity; of these, a high molecular weight enzyme was identified as DNA polymerase alpha because of its sensitivity to aphidicolin and to NEM. DNA polymerase mutants of Neurospora crassa were isolated by their resistance to aphidicolin, a specific inhibitor of the eukaryotic DNA polymerase alpha. Some...

Topics

Aphidicolin
Cosmids
Crosses, Genetic
DNA-Directed DNA Polymerase
Diterpenes
Drug Resistance, Microbial
Gene Library
Genes, Dominant
Genes, Fungal
Kinetics
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neurospora

Neurospora crassa

Source

Identifiers

PMID: 2144049

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2144049-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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