Isolation of Chinese hamster ovary cells with reduced poly(ADP-ribose) polymerase activity.

doi:10.1016/0027-5107(90)90032-y

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Article

Isolation of Chinese hamster ovary cells with reduced poly(ADP-ribose) polymerase activity.

Mutation research - 1 Aug 1990

MacLaren R A, Witmer M V, Richardson E, Stamato T D

Abstract excerpt

The biological function of poly(ADP-ribose) polymerase in DNA repair, cell-cycle regulation and cellular differentiation has yet to be defined. Isolation of cells which are deficient in poly(ADP-ribose) synthesis would greatly facilitate the determination of the biological role of this enzyme. A...

Topics

Animals
Cell Division
Cell Line
Cell Survival
Cricetinae
Ethyl Methanesulfonate
Kinetics
Mutation
Poly(ADP-ribose) Polymerases

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