On the DNA polymerase-a mutant: immunofluorescence assay of UV-induced thymidine dimers in Aphr-4-2 cells.

doi:10.1007/BF01650479

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Article

On the DNA polymerase-a mutant: immunofluorescence assay of UV-induced thymidine dimers in Aphr-4-2 cells.

Somatic cell and molecular genetics - 1 Jan 1990

Liu P K, Hsu G S

Abstract excerpt

Aphidicolin inhibits purified DNA polymerases-a and -d in vitro and inhibits mitosis in animal cells. The Chinese hamster V79 cell mutant, Aphr-4-2, was selected for its ability to form colonies in cultured medium supplemented with 1.0 microM aphidicolin. At this concentration, the parental wild-...

Topics

Animals
Aphidicolin
Cell Line
DNA Polymerase II
Diterpenes
Drug Resistance
Flow Cytometry
Fluorescent Antibody Technique
Mutation
Pyrimidine Dimers
Thymidine
Ultraviolet Rays

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