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Article

Calcium binding in the pore of L-type calcium channels modulates high affinity dihydropyridine binding.

The Journal of biological chemistry - 4 Aug 1995

Peterson B Z, Catterall W A

Abstract excerpt

The pore-forming alpha 1 subunit of L-type voltage-gated Ca2+ channels contains a Ca(2+)-binding site that is allosterically coupled to the receptor site for dihydropyridine (DHP) Ca2+ antagonists. Site-directed mutations of conserved Phe and Glu residues in the pore-lining SS1/SS2 segments greatly reduced Ca2+ enhancement of DHP binding. Substitution of Phe-1013 in the alpha 1 subunit from rabbit skeletal muscle...

Topics

Amino Acid Sequence
Barium
Binding Sites
Cadmium
Calcium
Calcium Channels
Calcium Channels, L-Type
Dihydropyridines
Glutamic Acid
Ion Channel Gating
Membranes
Models, Biological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Chemical

Molecular Sequence Data

Mutation

Protein Conformation

Radioligand Assay

Source

Identifiers

PMID: 7629136
DOI: 10.1074/jbc.270.31.18201

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7629136-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Calcium binding in the pore of L-type calcium channels modulates high affinity dihydropyridine binding.PMID 7629136Read ↗

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