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Article

Calcium binding in the pore of L-type calcium channels modulates high affinity dihydropyridine binding.

The Journal of biological chemistry - 4 Aug 1995

Peterson B Z, Catterall W A

Abstract excerpt

The pore-forming alpha 1 subunit of L-type voltage-gated Ca2+ channels contains a Ca(2+)-binding site that is allosterically coupled to the receptor site for dihydropyridine (DHP) Ca2+ antagonists. Site-directed mutations of conserved Phe and Glu residues in the pore-lining SS1/SS2 segments greatly reduced Ca2+ enhancement of DHP binding. Substitution of Phe-1013 in the alpha 1 subunit from rabbit skeletal muscle...

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Identifiers

PMID: 7629136
DOI: 10.1074/jbc.270.31.18201

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Calcium binding in the pore of L-type calcium channels modulates high affinity dihydropyridine binding.PMID 7629136Read ↗

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