Article
Activating the ryanodine receptor with dihydropyridine receptor II-III loop segments: size and charge do matter.
Frontiers in bioscience : a journal and virtual library - 1 Sept 2004
Casarotto Marco G, Green Daniel, Pace Suzy, Young Jaqui, Dulhunty Angela F
Abstract excerpt
Excitation-contraction coupling in skeletal muscle is thought to depend on a physical interaction between II-III loop of the alpha1 subunit of the skeletal dihydropyridine receptor (DHPR) and ryanodine receptor (RyR). A peptide corresponding to II-III loop residues 671-690 of the skeletal DHPR (peptide A) is a high affinity activator of the RyR when it adopts an alpha-helical structure with critical basic...
Topics
- Amino Acid Sequence
- Animals
- Calcium
- Calcium Channels, L-Type
- Circular Dichroism
- Magnetic Resonance Spectroscopy
- Molecular Conformation
- Molecular Sequence Data
- Muscle, Skeletal
- Mutation
- Peptides
- Protein Structure, Secondary
- Protein Structure, Tertiary