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Article

Molecular localization of ion selectivity sites within the pore of a human L-type cardiac calcium channel.

The Journal of biological chemistry - 25 Jun 1993

Tang S, Mikala G, Bahinski A, Yatani A, Varadi G, Schwartz A

Abstract excerpt

A highly conserved position of negatively charged amino acids is present in the SS2 segments of the S5-S6 linker regions among calcium channels. We report here that replacing Glu residues at this position alters the ion selectivity of the human cardiac calcium channel. Substituting Glu334 in motif I or Glu1086 in motif III with Lys produced mutant calcium channels that permeated sodium ions 10-fold more...

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PMID: 8099908

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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