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Article

Molecular determinants of drug binding and action on L-type calcium channels.

Annual review of pharmacology and toxicology - 1 Jan 1997

Hockerman G H, Peterson B Z, Johnson B D, Catterall W A

Abstract excerpt

The crucial role of L-type Ca2+ channels in the initiation of cardiac and smooth muscle contraction has made them major therapeutic targets for the treatment of cardiovascular disease. L-type channels share a common pharmacological profile, including high-affinity voltage- and frequency-dependent block by the phenylalkylamines, the benz(othi)azepines, and the dihydropyridines. These drugs are thought to bind to...

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PMID: 9131258
DOI: 10.1146/annurev.pharmtox.37.1.361

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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