Article
Molecular determinants of drug binding and action on L-type calcium channels.
Annual review of pharmacology and toxicology - 1 Jan 1997
Hockerman G H, Peterson B Z, Johnson B D, Catterall W A
Abstract excerpt
The crucial role of L-type Ca2+ channels in the initiation of cardiac and smooth muscle contraction has made them major therapeutic targets for the treatment of cardiovascular disease. L-type channels share a common pharmacological profile, including high-affinity voltage- and frequency-dependent...
Topics
- Amino Acid Sequence
- Benzazepines
- Binding Sites
- Calcium Channel Blockers
- Calcium Channels
- Dihydropyridines
- Humans
- Mutagenesis, Site-Directed
- Mutation
- Phenethylamines
- Protein Binding