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Article

Domain cooperativity in the β1a subunit is essential for dihydropyridine receptor voltage sensing in skeletal muscle.

Proceedings of the National Academy of Sciences of the United States of America - 30 Apr 2013

Dayal Anamika, Bhat Vinayakumar, Franzini-Armstrong Clara, Grabner Manfred

Abstract excerpt

The dihydropyridine receptor (DHPR) β1a subunit is crucial for enhancement of DHPR triad expression, assembly of DHPRs in tetrads, and elicitation of DHPRα1S charge movement--the three prerequisites of skeletal muscle excitation-contraction coupling. Despite the ability to fully target α1S into triadic junctions and tetradic arrays, the neuronal isoform β3 was unable to restore considerable charge movement...

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Identifiers

PMID: 23589859
DOI: 10.1073/pnas.1301087110
PMCID: PMC3645543

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Domain cooperativity in the β1a subunit is essential for dihydropyridine receptor voltage sensing in skeletal muscle.PMID 23589859Read ↗

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