Article
Domain cooperativity in the β1a subunit is essential for dihydropyridine receptor voltage sensing in skeletal muscle.
Proceedings of the National Academy of Sciences of the United States of America - 30 Apr 2013
Dayal Anamika, Bhat Vinayakumar, Franzini-Armstrong Clara, Grabner Manfred
Abstract excerpt
The dihydropyridine receptor (DHPR) β1a subunit is crucial for enhancement of DHPR triad expression, assembly of DHPRs in tetrads, and elicitation of DHPRα1S charge movement--the three prerequisites of skeletal muscle excitation-contraction coupling. Despite the ability to fully target α1S into triadic junctions and tetradic arrays, the neuronal isoform β3 was unable to restore considerable charge movement...
Topics
- Amino Acid Motifs
- Animals
- Calcium Channels, L-Type
- Excitation Contraction Coupling
- Green Fluorescent Proteins
- Humans
- Models, Biological
- Muscle Fibers, Skeletal
- Muscle, Skeletal
- Mutation
- Protein Isoforms
- Protein Subunits
- Recombinant Proteins