Article
Multiple loops of the dihydropyridine receptor pore subunit are required for full-scale excitation-contraction coupling in skeletal muscle.
Biophysical journal - 1 Jul 2005
Carbonneau Leah, Bhattacharya Dipankar, Sheridan David C, Coronado Roberto
Abstract excerpt
Understanding which cytosolic domains of the dihydropyridine receptor participate in excitation-contraction (EC) coupling is critical to validate current structural models. Here we quantified the contribution to skeletal-type EC coupling of the alpha1S (CaV1.1) II-III loop when alone or in combination with the rest of the cytosolic domains of alpha1S. Chimeras consisting of alpha1C (CaV1.2) with alpha1S...
Topics
- Aniline Compounds
- Animals
- Cadmium
- Calcium
- Calcium Channels, L-Type
- DNA
- DNA, Complementary
- Electrophysiology
- Fluorescent Dyes
- Genotype
- Kinetics
- Mice
- Mice, Transgenic
- Microscopy, Confocal