Differential contribution by conserved glutamate residues to an ion-selectivity site in the L-type Ca2+ channel pore.

doi:10.1016/0014-5793(93)80743-e

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Article

Differential contribution by conserved glutamate residues to an ion-selectivity site in the L-type Ca2+ channel pore.

FEBS letters - 6 Dec 1993

Mikala G, Bahinski A, Yatani A, Tang S, Schwartz A

Abstract excerpt

In voltage-gated cation channels, it is thought that residues responsible for ion-selectivity are located within the pore-lining SS1-SS2 segments. In this study, we compared the ion permeation properties of mutant calcium channels in which highly conserved glutamate residues, located at analogous...

Topics

Amino Acid Sequence
Barium
Binding Sites
Calcium Channels
Conserved Sequence
Glutamates
Glutamic Acid
Humans
Molecular Sequence Data
Mutation
Sequence Homology, Amino Acid
Sodium
Structure-Activity Relationship

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