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Article

Differential contribution by conserved glutamate residues to an ion-selectivity site in the L-type Ca2+ channel pore.

FEBS letters - 6 Dec 1993

Mikala G, Bahinski A, Yatani A, Tang S, Schwartz A

Abstract excerpt

In voltage-gated cation channels, it is thought that residues responsible for ion-selectivity are located within the pore-lining SS1-SS2 segments. In this study, we compared the ion permeation properties of mutant calcium channels in which highly conserved glutamate residues, located at analogous positions in the SS2 regions of all four motifs, were individually replaced. All of the mutants exhibited a loss of...

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PMID: 7902817
DOI: 10.1016/0014-5793(93)80743-e

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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