Article
Mechanism of magnesium activation of calcium-activated potassium channels.
Nature - 22 Aug 2002
Shi Jingyi, Krishnamoorthy Gayathri, Yang Yanwu, Hu Lei, Chaturvedi Neha, Harilal Dina, Qin Jun, Cui Jianmin
Abstract excerpt
Large-conductance (BK type) Ca(2+)-dependent K(+) channels are essential for modulating muscle contraction and neuronal activities such as synaptic transmission and hearing. BK channels are activated by membrane depolarization and intracellular Ca(2+) and Mg(2+) (refs 6-10). The energy provided by voltage, Ca(2+) and Mg(2+) binding are additive in activating the channel, suggesting that these signals open the...
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