Article
The carboxyl terminus of the gamma-subunit of rod cGMP phosphodiesterase contains distinct sites of interaction with the enzyme catalytic subunits and the alpha-subunit of transducin.
The Journal of biological chemistry - 2 Jun 1995
Skiba N P, Artemyev N O, Hamm H E
Abstract excerpt
The interaction between the GTP-bound form of the transducin alpha-subunit (G alpha t) and the gamma-subunit (P gamma) of cGMP phosphodiesterase (PDE) is a key event in effector activation during photon signal transduction. The carboxyl-terminal half of P gamma is involved in interaction with G a...
Topics
- 3',5'-Cyclic-GMP Phosphodiesterases
- Amino Acid Sequence
- Animals
- Base Sequence
- Binding Sites
- Catalysis
- Cattle
- Enzyme Activation
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Rod Cell Outer Segment
- Transducin