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Article

Identification of a novel site within G protein alpha subunits important for specificity of receptor-G protein interaction.

Molecular pharmacology - 1 Aug 2004

Heydorn Arne, Ward Richard J, Jorgensen Rasmus, Rosenkilde Mette M, Frimurer Thomas M, Milligan Graeme, Kostenis Evi

Abstract excerpt

Several domains of G protein alpha subunits are implicated in the control of receptor-G protein coupling specificity. Among these are the extreme N-and C-termini, the alpha4/beta6-loops, and the loop linking the N-terminal alpha-helix to the beta1-strand of the ras-like domain. In this study, we illustrate that single-point mutations of a highly conserved glycine residue within the linker I region of the...

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PMID: 15266015
DOI: 10.1124/mol.66.2.250

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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