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Article

Distinct sites on G protein beta gamma subunits regulate different effector functions.

The Journal of biological chemistry - 27 Sept 2002

Mirshahi Tooraj, Mittal Vivek, Zhang Hailin, Linder Maurine E, Logothetis Diomedes E

Abstract excerpt

G proteins interact with effectors at multiple sites and regulate their activity. The functional significance of multiple contact points is not well understood. We previously identified three residues on distinct surfaces of Gbetagamma that are crucial for G protein-coupled inward rectifier K(+) (GIRK) channel activation. Here we show that mutations at these sites, S67K, S98T, and T128F, abolished or reduced...

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Source

Identifiers

PMID: 12124391
DOI: 10.1074/jbc.M205359200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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