Article
Loss of association between activated Galpha q and Gbetagamma disrupts receptor-dependent and receptor-independent signaling.
Cellular signalling - 1 Oct 2005
Evanko Daniel S, Thiyagarajan Manimekalai M, Takida Satoshi, Wedegaertner Philip B
Abstract excerpt
The G protein subunit, betagamma, plays an important role in targeting alpha subunits to the plasma membrane and is essential for binding and activation of the heterotrimer by heptahelical receptors. Mutation of residues in the N-terminal alpha-helix of alpha s and alpha q that contact betagamma in the crystal structure of alpha i reduces binding between alpha and betagamma, inhibits plasma membrane targeting and...
Topics
- Acetylation
- Adrenergic alpha-Agonists
- Brimonidine Tartrate
- Cell Line
- Cell Membrane
- Cyclic AMP
- GTP-Binding Protein alpha Subunits
- GTP-Binding Protein alpha Subunits, Gq-G11
- GTP-Binding Protein beta Subunits
- GTP-Binding Protein gamma Subunits
- Heterotrimeric GTP-Binding Proteins
- Humans