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Article

Characterization of the GRK2 binding site of Galphaq.

The Journal of biological chemistry - 17 Dec 2004

Day Peter W, Tesmer John J G, Sterne-Marr Rachel, Freeman Leslie C, Benovic Jeffrey L, Wedegaertner Philip B

Abstract excerpt

Heterotrimeric guanine nucleotide-binding proteins (G proteins) transmit signals from membrane bound G protein-coupled receptors (GPCRs) to intracellular effector proteins. The G(q) subfamily of Galpha subunits couples GPCR activation to the enzymatic activity of phospholipase C-beta (PLC-beta). Regulators of G protein signaling (RGS) proteins bind to activated Galpha subunits, including Galpha(q), and regulate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dimerization

Share to GTP-Binding Protein alpha Subunits, Gq-G11

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Share to Phospholipase C beta

Share to Type C Phospholipases

Source

Open in PubMed Open full text

Identifiers

PMID: 15471870
DOI: 10.1074/jbc.M401438200
PMCID: PMC1432089

Genes

GRK2
RGS2
RGS4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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