Article
Frequent loss of heterozygosity on chromosome 4 in diethylnitrosamine-induced C3H/MSM mouse hepatocellular carcinomas in culture.
Molecular carcinogenesis - 1 May 1995
Miyasaka K, Ohtake K, Nomura K, Kanda H, Kominami R, Miyashita N, Kitagawa T
Abstract excerpt
Genetic changes, in particular the loss of heterozygosity (LOH) and the presence of c-Ha-ras codon 61 point mutations, were investigated in diethylnitrosamine-induced hepatocellular carcinomas (HCCs) in C3H/MSM F1 mice. (MSM are wild mice.) LOH analysis of 48 primary tumors with microsatellite pr...
Topics
- Alleles
- Animals
- Base Sequence
- Chromosomes
- Diethylnitrosamine
- Female
- Gene Deletion
- Genes, ras
- Heterozygote
- Liver Neoplasms, Experimental
- Male
- Mice
- Mice, Inbred C3H
- Molecular Sequence Data
- Point Mutation
- Skin Neoplasms
- Tumor Cells, Cultured