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Article

Mouse mammary tumor virus/v-Ha-ras transgene-induced mammary tumors exhibit strain-specific allelic loss on mouse chromosome 4.

Proceedings of the National Academy of Sciences of the United States of America - 5 Aug 1997

Radany E H, Hong K, Kesharvarzi S, Lander E S, Bishop J M

Abstract excerpt

Hybrid mice carrying oncogenic transgenes afford powerful systems for investigating loss of heterozygosity (LOH) in tumors. Here, we apply this approach to a neoplasm of key importance in human medicine: mammary carcinoma. We performed a whole genome search for LOH using the mouse mammary tumor virus/v-Ha-ras mammary carcinoma model in female (FVB/N x Mus musculus castaneus)F1 mice. Mammary tumors developed as...

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Identifiers

PMID: 9238034
DOI: 10.1073/pnas.94.16.8664
PMCID: PMC23068

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