Mouse mammary tumor virus/v-Ha-ras transgene-induced mammary tumors exhibit strain-specific allelic loss on mouse chromosome 4.

doi:10.1073/pnas.94.16.8664

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Article

Mouse mammary tumor virus/v-Ha-ras transgene-induced mammary tumors exhibit strain-specific allelic loss on mouse chromosome 4.

Proceedings of the National Academy of Sciences of the United States of America - 5 Aug 1997

Radany E H, Hong K, Kesharvarzi S, Lander E S, Bishop J M

Abstract excerpt

Hybrid mice carrying oncogenic transgenes afford powerful systems for investigating loss of heterozygosity (LOH) in tumors. Here, we apply this approach to a neoplasm of key importance in human medicine: mammary carcinoma. We performed a whole genome search for LOH using the mouse mammary tumor virus/v-Ha-ras mammary carcinoma model in female (FVB/N x Mus musculus castaneus)F1 mice. Mammary tumors developed as...

Topics

Alleles
Animals
Carcinoma
Female
Gene Deletion
Gene Transfer Techniques
Genes, ras
Humans
Mammary Neoplasms, Experimental
Mammary Tumor Virus, Mouse
Mice
Mice, Transgenic
Retroviridae Infections

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Species Specificity

Tumor Virus Infections

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Identifiers

PMID: 9238034
DOI: 10.1073/pnas.94.16.8664
PMCID: PMC23068

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