Article
Hepatocarcinogenesis in rodents and humans.
Journal of cancer research and clinical oncology - 1 Jan 1995
Kitagawa T, Miyasaka K, Kanda H, Yasui H, Hino O
Abstract excerpt
In hepatocarcinogenesis in rodents, induction of foci and nodules comprising clonally proliferated initiated cells is considered to be essential for the future development of carcinomas. Nodules in human cirrhotic liver, though known to be associated with a high hepatocellular carcinoma risk, have generally been regarded as regenerative in nature, and not the result of clonal or neoplastic cell proliferation, on...
Topics
- Alleles
- Animals
- Carcinoma, Hepatocellular
- Cell Division
- DNA, Neoplasm
- Humans
- Liver Cirrhosis
- Liver Neoplasms
- Liver Neoplasms, Experimental
- Mice
- Sequence Deletion