Homozygous Deletion Scanning in Hepatobiliary Tumor Cell Lines Reveals Alternative Pathways for Liver Carcinogenesis

Abstract excerpt

Despite high rates of loss of heterozygosity affecting various chromosomes, the number of tumor suppressor genes (TSGs) found to be consistently involved in primary liver cancer is low. In the past decade, characterization of homozygous deletions (HDs) in tumors has become instrumental to identify new TSGs or to reveal the influence of a particular TSG on the development of a specific tumor type. We performed a...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cancer-related gene regulation
• Share to Genetic factors in colorectal cancer
• Share to RNA modifications and cancer