Article
In vivo mutation at the human HPRT locus.
Trends in genetics : TIG - 1 Sept 1993
Cariello N F, Skopek T R
Abstract excerpt
The molecular nature of mutations that arise in vivo at the human hypoxanthine-guanine phosphoribosyltransferase (HPRT) locus can be determined. A wide variety of such mutations can be detected, including large and small deletions, frameshift mutations and single-base substitutions, as well as al...
Topics
- Adult
- Cells, Cultured
- DNA Mutational Analysis
- Exons
- Frameshift Mutation
- Genes
- Gout
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Infant, Newborn
- Lesch-Nyhan Syndrome
- Mutation
- Point Mutation
- RNA Splicing
- Sequence Deletion
- Smoking
- T-Lymphocytes
- X Chromosome