Molecular spectrum of background mutation at the hprt locus in human T-lymphocytes.

doi:10.1093/mutage/8.1.43

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Article

Molecular spectrum of background mutation at the hprt locus in human T-lymphocytes.

Mutagenesis - 1 Jan 1993

Hou S M, Steen A M, Fält S, Andersson B

Abstract excerpt

The molecular basis of somatic mutation at the hypoxanthine-guanine phosphoribosyl-transferase (hprt) locus in human 6-thioguanine resistant T-cell clones from 17 individuals has been studied by Southern blot analysis, multiplex PCR (polymerase chain reaction) and direct sequencing of PCR amplifi...

Topics

Adult
Base Sequence
Cells, Cultured
DNA
DNA, Single-Stranded
Exons
Female
Frameshift Mutation
Genes
Humans
Hypoxanthine Phosphoribosyltransferase
Male
Middle Aged
Molecular Sequence Data
Mutagenicity Tests
Mutation
Polymerase Chain Reaction
RNA Splicing

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