Article
In vivo antagonism of a T cell response by an endogenously expressed ligand.
Proceedings of the National Academy of Sciences of the United States of America - 24 Nov 1998
Basu D, Williams C B, Allen P M
Abstract excerpt
3.L2 T cell receptor transgenic T cells are activated by the 64-76 peptide of the mouse hemoglobin d beta chain [Hb(64-76)], and their response is antagonized by the position 72 alanine substitution of this peptide (A72). To test the effect of this altered peptide ligand (APL) on 3.L2 T cell func...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Cells, Cultured
- Crosses, Genetic
- Flow Cytometry
- Hemoglobins, Abnormal
- Histocompatibility Antigens Class II
- Lymphocyte Activation
- Mice
- Mice, Transgenic
- Peptide Fragments
- Receptors, Antigen, T-Cell
- T-Lymphocytes