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Article

In vivo antagonism of a T cell response by an endogenously expressed ligand.

Proceedings of the National Academy of Sciences of the United States of America - 24 Nov 1998

Basu D, Williams C B, Allen P M

Abstract excerpt

3.L2 T cell receptor transgenic T cells are activated by the 64-76 peptide of the mouse hemoglobin d beta chain [Hb(64-76)], and their response is antagonized by the position 72 alanine substitution of this peptide (A72). To test the effect of this altered peptide ligand (APL) on 3.L2 T cell function in vivo, a transgene expressing A72 in major histocompatibility complex II positive cells (A72tg) has been...

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Identifiers

PMID: 9826700
DOI: 10.1073/pnas.95.24.14332
PMCID: PMC24373

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